After Christopher Durang’s uproarious comedy Vanya and Sonia and Masha and Spike made its Broadway debut in 2013, it took home the coveted Tony Award for Best Play. Now it makes its Hub premiere at the Boston University Theatre courtesy of the Huntington Theatre Company. Using the timeless works of Russian playwright Anton Chekhov as a jumping off point, the show depicts siblings Vanya and Sonia as their quiet life in the country is upended by the arrival of their movie star sister Masha with dim-witted boy toy Spike in tow. Combining Chekhovian themes of loss and disappointment with Disney, voodoo and The Beatles, Durang’s latest masterpiece will leave audiences howling.