Wildly successful actor/comedian and Massachusetts native Denis Leary (pictured) has always honored his roots in the area, and nowhere is this more evident than with the annual Comics Come Home benefit. Now in its fourth year at TD Garden and its 23rd overall, the Leary-hosted comedy extravaganza—which raises money for the Cam Neely Foundation for Cancer Care—takes place November 18 and features such marquee talent as “The Tonight Show”’s Jimmy Fallon, former late-night TV host Craig Ferguson, national headliners Robert Kelly and Jim Gaffigan, local legend Lenny Clarke and roast-master extraordinaire Jeff Ross. With a laugh-a-minute lineup like that, Comics Come Home promises to be the comedy event of the fall.